Heart failure & cardiomyopathies
Prognostic impact of acute decompensated heart failure in patients with heart failure with mildly reduced ejection fraction
Main findingResult — go to the resultHazard ratio 2.269 95% CI 1.939–2.656Authors' conclusion
ADHF is a common finding in patients with HFmrEF associated with an adverse impact on long-term prognosis.
Study context
- Population
- Consecutive patients hospitalised with heart failure with mildly reduced ejection fraction (HFmrEF) (LVEF 41–49% and signs and/or symptoms of heart failure (HF)), one institution, 2016–2022Acute decompensated heart failure (ADHF) in 22%
- Participants
- 2,184 patients
- Exposure
- ADHF vs no ADHF
- Outcome
- Long-term all-cause mortality
- Follow-up
- 30 months
Methodological detailssingle-centre, propensity-score matched
- Single-centre
- Propensity-score matched
Main finding
As reported in the abstract
Hazard ratio
2.269
95% CI 1.939–2.656
P = 0.001
By group
ADHFvs non-ADHF
HR 2.269 (95% CI 1.939–2.656); P = 0.001
Observational data: associations, not effects.
Secondary outcomes
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Long-term HF-related re-hospitalization, by history of previous ADHF before index hospitalization · 30 monthsPrevious ADHFvs No previous ADHF42% vs. 23% | 2.073 (1.420–3.027) | P = 0.001 | |
| 0.20.5125Hazard ratio (log scale) |
Long-term all-cause mortality, by history of previous ADHF · 30 months
- Previous ADHF not associated with long-term all-cause mortality
- P = 0.264
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Prognostic impact of acute decompensated heart failure in patients with heart failure with mildly reduced ejection fraction. Eur Heart J Acute Cardiovasc Care. Published 10 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →