Arrhythmias & electrophysiology
Prognostic impact of atrio-ventricular conduction abnormalities in non-ischemic cardiomyopathy
Authors' conclusion
AVB is a strong and independent predictor of VA and sudden death in NICM, in addition to LGE and LVEF. In addition, AVB has a significant impact on the risk stratification of LGE+ cases, identifying a small sub-group of patients with extremely high arrhythmic risk.
Study context
- Population
- Patients with non-ischemic cardiomyopathy (NICM), with assessment of atrioventricular block (AVB) at electrocardiogram (ECG) and late gadolinium enhancement (LGE) at cardiac magnetic resonance (CMR)
- Participants
- 616 patients
- Exposure
- AVB as a predictor of ventricular arrhythmias (VA) in NICM, in addition to LGE and LVEF
- Outcome
- Primary arrhythmic end point:
- Any appropriate implantable cardioverter defibrillator therapy
- Sustained monomorphic ventricular tachycardia
- Resuscitated cardiac arrest
- Sudden death
Main finding
As reported in the abstract
Hazard ratio
2.7
P = 0.007
independent of LGE and LVEF
Adjusted hazard ratio
3.4
P < 0.001
among LGE+ patients
Observational data: associations, not effects.
Further findings
Prevalence of AVB
- AVB observed
- 9%
LVEF
- LVEF, AVB vs no AVB
- 29% vs 37%, P < .001
Prevalence of LGE
- LGE, AVB vs no AVB
- 63% vs 46%, P = .02
Secondary heart failure (HF) end point
- AV block not a significant predictor at multivariate analysis
- P = 0.11
Original publication
Prognostic impact of atrio-ventricular conduction abnormalities in non-ischemic cardiomyopathy. Heart Rhythm. Published 28 July 2025. doi:10.
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