Valvular & structural heart disease

Prognostic Impact of Being Underweight in Patients Undergoing Mitral TEER: The OCEAN-Mitral Registry

ESC Heart FailPublished Prospective cohort study

Authors' conclusion

Underweight patients had the highest mortality rate after M-TEER. Comorbidities, residual MR, discharge disposition and underweight status were correlated with postprocedural outcome.

Study context

Population
Patients undergoing mitral TEER for severe mitral regurgitation (MR), April 2018–June 2021 (OCEAN-Mitral registry)median body mass index (BMI) 21.1 kg/m²
Participants
2,149 patients
Exposure
Underweight vs normal weight vs overweight and obese
  • Underweightn = 450
  • Normal weightn = 1,409reference
  • Overweight and obesen = 290
Outcome
All-cause, CV and non-CV mortality following mitral transcatheter edge-to-edge repair (M-TEER)
Follow-up
436 (363-733) days
Methodological detailsmulticentre registry
  • Multicentre registry

Main finding

As reported in the abstract

Underweight vs Normal weightHazard ratio (95% CI)P value
All-cause mortality; multivariate
1.52(1.17–1.97)
P = 0.009
CV mortality; multivariate
1.45(1.04–2.01)
P = 0.028

Observational data: associations, not effects.

Original publication

Prognostic Impact of Being Underweight in Patients Undergoing Mitral TEER: The OCEAN-Mitral Registry. ESC Heart Fail. Published 23 September 2024. doi:10.1002/ehf2.15047

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