Valvular & structural heart disease
Implications of myocardial strain in primary mitral regurgitation—a cardiovascular magnetic resonance study
Main findingResult — go to the resultHazard ratio 1.90Authors' conclusion
In patients with primary MR with preserved systolic function, GLS was associated with our composite outcomes and all-cause death.
Study context
- Population
- Patients undergoing cardiovascular magnetic resonance (CMR) for chronic primary mitral regurgitation (MR) with LVEF ≥50%, January 2012 to June 201893 met primary endpoint
- Participants
- 422 patients
- Exposure
- Global longitudinal strain (GLS)≥ −16.6% vs GLS< −16.6%
- Outcome
- Composite of:
- Referral for mitral surgery owing to symptoms or left ventricular (LV) systolic dysfunction
- CV death
- Follow-up
- Median 2.7 years
Methodological detailsconsecutive patients, CMR feature tracking
- Consecutive patients
- CMR feature tracking
Main finding
As reported in the abstract
Hazard ratio
1.90
P = 0.01
Observational data: associations, not effects.
Secondary outcomes
| Outcome | HR | P value |
|---|---|---|
| All-cause death (GLS≥ −16.0%) · adjusted for covariates including MR severity | 2.24 | P = 0.02 |
Event-free survival, by MR severity (subgroup)
- Moderate MR: worse event-free survival with GLS≥ −16.6%
- Mild or severe MR: no significant difference
Original publication
Implications of myocardial strain in primary mitral regurgitation—a cardiovascular magnetic resonance study. Eur Heart J Cardiovasc Imaging. Published 19 September 2024. doi:10.
Summarised from the published abstract; every number is checked against it