Arrhythmias & electrophysiology
Prognostic impact of diagnosis-to-ablation time on outcomes following catheter ablation in persistent atrial fibrillation and left ventricular systolic dysfunction
Authors' conclusion
In individuals with AF and LVSD, shorter DAT was associated with greater LVEF improvement and arrhythmia-free survival with lower AF burden and rehospitalization at 12 months
Study context
- Population
- Patients with persistent atrial fibrillation (AF) and LV systolic dysfunction undergoing catheter ablationmedian diagnosis to ablation time (DAT) 24 months
- Participants
- 210 patients
- Comparison
- Shorter vs longer AF diagnosis-to-ablation time before catheter ablation
- Primary endpoint
- Freedom from recurrent atrial arrhythmias
- Follow-up
- 12 months
Methodological detailspooled analysis
- Pooled analysis
Primary result
As reported in the abstract
Hazard ratio
1.63
95% CI 1.01–2.65
P = 0.040
By group
Further findings
LVEF · 12 months
P = 0.009
LV recovery (LVEF ≥ 50%) · 12 months
P = 0.011
| Outcome | Shorter DAT | Longer DAT | P value |
|---|---|---|---|
| AF burdenMedian | 0% (IQR 0.0–2.0%) | 0% (IQR 0.0–7.3%) | P = 0.017 |
| LVEF improvement · 12 months | +20.8 (SD 13.0) % | +13.9 (SD 13.2) % | P < 0.001 |
LA global and posterior wall scar (<0.05 mV)
- Lower with shorter DAT
- both P < .05
Hospitalizations and electrical cardioversions · 12 months
- Fewer with shorter DAT
Original publication
Prognostic impact of diagnosis-to-ablation time on outcomes following catheter ablation in persistent atrial fibrillation and left ventricular systolic dysfunction. Heart Rhythm. Published 27 September 2024. doi:10.
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