Acute cardiac care & resuscitation
Heart Failure Decompensation with Cardiogenic Shock Exhibits Distinct Sequential Inflammatory Profiles
Authors' conclusion
ADHF-CS is characterized by high levels of pro-inflammatory cytokines and total white count, compared with ambulatory HF. Decompensation from HF has two distinct inflammatory phases that may help identify outpatients at risk of CS.
Study context
- Population
- Patients with acute decompensated heart failure and cardiogenic shock admitted to a cardiac intensive care unit, and outpatients with HF with stored biospecimensADHF-CS Eighty-four · pre-CS Thirty-six · stable HF 338
- Comparison
- ADHF-CS vs stable HF (and pre-CS outpatients); differences between groups analysed by comparing means
- ADHF-CSn = Eighty-four
- pre-CSn = Thirty-six
- stable HFn = 338
Methodological details48-plex cytokine and white blood cell differential testing, single cardiac intensive care unit (CICU)
- 48-plex cytokine and white blood cell differential testing
- Single CICU
Main finding
As reported in the abstract
Pro-inflammatory cytokine levels (IL-1, IL-6, IL-8) and total white cell counts
- Cytokine profiles differed between ADHF-CS and stable HF
- Patients with cardiogenic shock (CS) had higher pro-inflammatory cytokine levels [including interleukin-1 (IL-1), interleukin-6 (IL-6) and interleukin-8 (IL-8)] and total white cell counts than stable HF patients
Further findings
| Outcome | ADHF-CS | pre-CS | Stable HF | |
|---|---|---|---|---|
| Timing of sample acquisition | median days after CICU admission 2 (IQR 0–7) days | days before admission with CS 137 (IQR 41–258) days | Not reported in the abstract | stable HF: not reported in the abstract |
Inflammatory profile of pre-CS outpatients
- Analysis of the pre-CS outpatient group suggested an intermediate stage in subacute transition to CS
Original publication
Heart Failure Decompensation with Cardiogenic Shock Exhibits Distinct Sequential Inflammatory Profiles. ESC Heart Fail. Published 9 February 2025. doi:10.
Summarised from the published abstract; every number is checked against it