Coronary disease & ACSCohort study
Prognostic impact of reduced kidney function in patients with suspected coronary artery disease undergoing coronary computed tomography angiography (CCTA)
- Cohort study
- consecutive patients
Authors' conclusion
In patients referred for CCTA due to suspected CAD, reduced kidney function was associated with an increased rate of MACE.
Study context
- Population
- Consecutive symptomatic patients with suspected coronary artery disease (CAD) undergoing CCTA, 2008–2021
- Participants
- 70,367 patients
- Exposure
- Reduced estimated glomerular filtration rate (eGFR) vs eGFR ≥90
- eGFR ≥90n = 41,156reference
- eGFR 60-89n = 27,011
- eGFR 30-59n = 2,200
- Outcome
- Major adverse cardiovascular events (MACE):
- MI
- Ischemic stroke
- CV death
- Follow-up
- Median 5.1 years
Main finding
As reported in the abstract
MACE
Each group vs eGFR ≥90Hazard ratio (95% CI)
eGFR 60-89
1.09(1.00–1.19)
eGFR 30-59
1.42(1.18–1.69)
Observational data: associations, not effects.
Further findings
MACE rate per 1000 person-years, obstructive CAD (subgroup)
MACE rate per 1000 person-years, non-obstructive CAD (subgroup)
Original publication
Prognostic impact of reduced kidney function in patients with suspected coronary artery disease undergoing CCTA. Eur J Prev Cardiol. Published 18 April 2025. doi:10.1093/eurjpc/zwaf218
Summarised from the published abstract; every number is checked against it