Acute cardiac care & resuscitation
Prognostic Impact of Society for Cardiovascular Angiography and Interventions (SCAI) Shock Severity Classes in AMI-Related Cardiogenic Shock: A Sub-Study of the ECLS-SHOCK Trial
Authors' conclusion
In AMI-CS patients included in the ECLS-SHOCK trial, SCAI stages at admission were predictive for mortality and for the incidence of safety events. The efficacy of ECLS treatment was not affected by SCAI stage.
Study context
- Population
- Patients with acute myocardial infarction complicated by cardiogenic shock (AMI-CS) enrolled in the ECLS-SHOCK trial between June 2019 and November 2022patients enrolled in the ECLS-SHOCK trial · SCAI Stage C 215 · SCAI Stage D 56 · SCAI Stage E 146
- Participants
- 417 patients
- Comparison
- Outcomes, treatment effect and safety of ECLS stratified according to SCAI stage at admission
- SCAI Stage Cn = 215
- SCAI Stage Dn = 56
- SCAI Stage En = 146
Methodological detailsmulticentre, randomized, post-hoc classification
- Multicentre
- Randomized
- Post-hoc classification
Primary result
As reported in the abstract
30 day all-cause mortality · 30 day
Further findings
| Outcome | Values |
|---|---|
| Renal replacement therapy · 30 days | SCAI Stage C 7.0% · SCAI Stage D 19.6% · SCAI Stage E 13.7% |
| Poor neurological outcomes | SCAI Stage C 17.2% · SCAI Stage D 44.4% · SCAI Stage E 36.5% |
- Renal replacement therapy: P = 0.03
- Poor neurological outcomes: P < 0.001
30 day all-cause mortality, ELCS vs. control by SCAI stage (subgroup)
- SCAI C: ELCS vs. control
- 32.7% vs. 32.4%
- SCAI D: ELCS vs. control
- 68.4% vs. 66.7%
- SCAI E: ELCS vs. control
- 59.7% vs. 68.4%
- No interaction was observed between SCAI stage and the treatment effect of ELCS on 30 day all-cause mortality
- P for interaction = 0.65
Original publication
Prognostic Impact of SCAI Shock Severity Classes in AMI-Related Cardiogenic Shock: A Sub-Study of the ECLS-SHOCK Trial. ESC Heart Fail. Published 13 October 2025. doi:10.
Summarised from the published abstract; every number is checked against it