Heart failure & cardiomyopathies
Prognostic impact of precipitated cardiac decompensation in symptomatic heart failure with reduced ejection fraction and severe secondary mitral regurgitation
Authors' conclusion
In heart failure with reduced ejection fraction and severe secondary mitral regurgitation patients, primary heart failure decompensations were 3-times more frequent compared to precipitated decompensations with a nonsignificant trend in increased risk of all-cause mortality.
Study context
- Population
- Symptomatic HF with severe secondary mitral regurgitation on guideline-directed medical therapy, randomised to medical therapy alone or with percutaneous mitral valve repair
- Participants
- 304 participants
- Comparison
- Primary vs secondary HF decompensation vs no HF event
- Primary endpoint
- All-cause mortality
- Follow-up
- 2 years
Primary result
As reported in the abstract
Hazard ratio (95% CI)P value
Only primary decompensationvs No HF decompensation
4.87(2.86–8.32)
Only secondary decompensationvs No HF decompensation
2.68(1.64–4.37)
Only primary decompensationvs Only secondary decompensation
1.82(0.93–3.58)
P = 0.082Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Mortality per additional HF recurrence | 1.27 (1.08–1.50) | P = 0.005 | |
| 0.512Hazard ratio (log scale) |
Mean
| Outcome | Only primary decompensation | Only secondary decompensation | P value |
|---|---|---|---|
| Mean number of HF decompensationsOnly primary decompensation vs Only secondary decompensation · similar | 1.94 (SD 1.39) | 1.80 (SD 1.07) | P = 0.480 |
≥1 HF decompensation within 24 months
- Patients with ≥1 HF decompensation
- 179 (59 %)
- First decompensation primary
- 129 (72%)
- First decompensation secondary
- 50 (28%)
Original publication
Prognostic impact of precipitated cardiac decompensation in symptomatic heart failure with reduced ejection fraction and severe secondary mitral regurgitation. Am Heart J. Published 2 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →