Prognostic Impact of Ventricular Arrhythmia Timing in Acute Coronary Syndromes Treated with Percutaneous Coronary Intervention: A Systematic Review and Network Meta-Analysis
Pooled result · Short-term mortalityResult — go to the resultOdds ratio 5.04 95% CI 3.78–6.72Authors' conclusion
VA substantially increase the risk of death in patients with ACS undergoing PCI. Mortality risk emerges to be associated with the timing of VA occurrence, with VA-after PCI associated with the highest risk. These findings highlight the prognostic relevance of arrhythmic events across the entire peri-procedural window, underscoring the need for refined risk stratification.
Study context
- Population
- Acute coronary syndromes (ACS) patients undergoing percutaneous coronary intervention (PCI)Twelve studies, of whom 3,475 (7.0%) experienced ventricular arrhythmias (VA)
- Participants
- 49,963 patients
- Comparison
- VA-before PCI, VA-during PCI, and VA-after PCI with the group not experiencing VA as a reference
- VAn = 3,475
- Outcome
- Short-term mortality
- Follow-up
- 30 days/in-hospital
Methodological detailsnetwork meta-analysis
- Network meta-analysis
Pooled result
As reported in the abstract
Odds ratio
5.04
95% CI 3.78–6.72
VA vs no VA
OR 5.04 (95% CI 3.78–6.72)
Further pooled results
| Outcome | OR (95% CI) | |
|---|---|---|
| Long-term mortality · 1 yearVA vs no VA | 2.92 (2.20–3.86) | |
| Subsequent long-term mortality in patients alive at discharge/30 daysVA vs no VA | 0.97 (0.62–1.52) | |
| Short-term mortality, VA-after vs earlier VA (sensitivity analysis)Higher with VA-after · sensitivity analysis | 3.37 (1.46–7.82) | |
| 0.10.31310Odds ratio (log scale) |
Mortality by VA timing (network meta-analysis)
- All VA timings associated with a significantly higher risk compared with the group not experiencing VA
Original publication
Prognostic Impact of Ventricular Arrhythmia Timing in Acute Coronary Syndromes Treated with Percutaneous Coronary Intervention: A Systematic Review and Network Meta-Analysis. Heart Rhythm. Published 22 October 2026. doi:10.
Summarised from the published abstract; every number is checked against it