Timing of Complete Multivessel Revascularization in Acute Coronary Syndrome: 2-Year Results of the BIOVASC Study
Authors' conclusion
In patients with ACS and multivessel disease, there was no significant difference between immediate complete revascularization and staged complete revascularization with respect to the composite outcome of all-cause mortality, myocardial infarction, any unplanned ischemia-driven revascularization, and cerebrovascular event at 2 years.
Study context
- Population
- Patients with acute coronary syndromes (ACS) and multivessel coronary diseasefollow-up complete 97.6%
- Participants
- 764 vs 761
- Comparison
- Immediate vs staged complete revascularization
- Immediate complete revascularizationn = 764
- Staged complete revascularizationn = 761reference
- Primary endpoint
- Composite of:
- All-cause mortality
- MI
- Any unplanned ischemia-driven revascularization
- Cerebrovascular event
- Follow-up
- 2 years
Methodological detailsnon-inferiority, multicentre (29 sites in Europe), 2-year follow-up
- Non-inferiority
- Multicentre (29 sites in Europe)
- 2-year follow-up
Primary result
As reported in the abstract
Hazard ratio
0.98
95% CI 0.73–1.30
P = 0.88
By group
Immediate complete revascularization vs Staged complete revascularization
HR 0.98 (95% CI 0.73–1.30); P = 0.88
Further findings
| Outcome | Immediate complete revascularization | Staged complete revascularization | HR (95% CI) | P value | |
|---|---|---|---|---|---|
| MI · 2 years | 3.8% | 6.2% | 0.60 (0.37–0.96) | P = 0.032 | |
| All-cause mortality · 2 years | 3.3% | 2.0% | 1.67 (0.88–3.16) | P = 0.12 | |
| Any unplanned ischemia-driven revascularization · 2 years | 7.0% | 7.9% | 0.87 (0.60–1.26) | P = 0.57 | |
| Cerebrovascular event · 2 years | 2.5% | 1.7% | 1.39 (0.68–2.83) | P = 0.37 | |
| 0.20.5125Hazard ratio (log scale) |
Original publication
Timing of Complete Multivessel Revascularization in Acute Coronary Syndrome: 2-Year Results of the BIOVASC Study. JACC Cardiovasc Interv. Published 23 December 2024. doi:10.
Summarised from the published abstract; every number is checked against it