Valvular & structural heart disease
Prognostic implications of moderate aortic stenosis with concomitant aortic regurgitation in degenerative aortic valve disease: insights from a multicentre cohort
Authors' conclusion
Moderate ASR should not be considered a benign condition, as it is associated with poor clinical outcomes comparable to those of severe AS.
Study context
- Population
- Patients with degenerative aortic valve disease in a multicentre valvular heart disease cohort, 2008–2022final analysis
- Participants
- 4,395 patients
- Exposure
- Concomitant moderate aortic stenosis (AS) and moderate aortic regurgitation vs isolated AS
- Moderate ASRn = 224
- Severe ASn = 1,996reference
- Moderate ASn = 2,175reference
- Outcome
- Composite of:
- Cardiac death
- Hospitalization for heart failure
- Follow-up
- Median 3.4 years
Methodological detailsthree tertiary centres
- Three tertiary centres
Main finding
As reported in the abstract
Adjusted hazard ratio (95% CI)P value
Moderate ASRvs moderate AS
1.49(1.15–1.92)
P = 0.002Moderate ASRvs severe ASrisk comparable to severe AS
1.28(1.00–1.64)
P = 0.052Observational data: associations, not effects.
Further findings
Aortic valve replacement (AVR) rates · median follow-up of 3.4 years
- Aortic valve replacement (AVR) rates: P < 0.001
Independent predictors of the primary outcome in moderate ASR
- Older age, male sex, renal dysfunction, and lower left ventricular ejection fraction
Original publication
Prognostic implications of moderate aortic stenosis with concomitant aortic regurgitation in degenerative aortic valve disease: insights from a multicentre cohort. Eur Heart J Cardiovasc Imaging. Published 11 September 2025. doi:10.
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