Valvular & structural heart disease
Prognostic value of leaflet coaptation gap in transcatheter edge-to-edge repair for functional mitral regurgitation
Authors' conclusion
CG was associated with less MR reduction but with no clear difference in adverse clinical outcomes after TEER. Similar outcomes between residual MR grade 2+ and ≤1+ in CG patients highlight the importance of procedural endpoint in anatomically challenging cases.
Study context
- Population
- Patients undergoing mitral transcatheter edge-to-edge repair (TEER) for functional mitral regurgitation (MR)patients undergoing TEER for functional MR · coaptation gap (CG) 219 · no CG 1,921
- Participants
- 2,140 patients
- Comparison
- Patients with CG vs patients without CG
- Outcome
- Composite of:
- Death
- Heart failure hospitalisation
- Mitral valve reintervention (cumulative incidence)
- Follow-up
- 3 years
Main finding
As reported in the abstract
P = 0.71
Further findings
Achievement of MR grade ≤2+ and ≤1+ · Post-TEER
MR grade ≤2+
P < 0.01
MR grade ≤1+
P < 0.01
- Primary outcome by residual MR grade 2+ vs ≤1+ (subgroup)
- P < 0.01
- Primary outcome by residual MR grade 2+ vs ≤1+ (subgroup) · patients with CG; no significant difference
- P = 0.51
- Primary outcome by residual MR grade 2+ vs ≤1+ (subgroup): patients without CG; higher primary outcome incidence with residual MR grade 2+
Baseline characteristics and procedure
- In patients with CG, baseline MR grade and New York Heart Association (NYHA) functional class were more severe, and long/wide clip types were used more frequently
NYHA functional class · 1 year
- Similar in both groups
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Prognostic value of leaflet coaptation gap in transcatheter edge-to-edge repair for functional mitral regurgitation. Heart. Published 8 September 2025. doi:10.
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