Prognostic implications of myocardial perfusion imaging by 82-rubidium positron emission tomography in male and female patients with angina and no perfusion defects
Authors' conclusion
MFR, LVEF, and LVEF-reserve derived from 82Rb-PET provide prognostic information on cardiovascular outcomes in patients with no perfusion defects.
Study context
- Population
- Patients with symptoms suggestive of stable coronary artery disease (CAD) and no regional perfusion defects on 82Rb-PET, January 2018–August 2020of 3726 screened
- Participants
- 2,175 patients
- Outcome
- Composite of:
- All-cause mortality
- Hospitalization for unstable angina
- Acute MI
- HF
- Ischaemic stroke
- Follow-up
- Median 1.7 years (IQR 1.1-2.5 years)
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
Composite endpoint (multivariable Cox model)
Estimate (95% CI)
MFR < 2
HR 1.75(1.24–2.48)
LVEF
HR 1.38 per 10% decrease(1.24–1.54)
LVEF-reserve
HR 1.19 per 5% decrease(1.07–1.31)
Each row per its own increment, as printed
- Endpoints
- 148
Observational data: associations, not effects.
Further findings
Subgroups by gender, history of ischaemic heart disease, low left ventricular ejection fraction (LVEF), AF
- Results consistent across subgroups
Original publication
Prognostic implications of myocardial perfusion imaging by 82-rubidium positron emission tomography in male and female patients with angina and no perfusion defects. Eur Heart J Cardiovasc Imaging. Published 17 November 2022. doi:10.
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