Valvular & structural heart disease
Prognostic Implications of Discordant Low-Gradient Severe Aortic Stenosis: Comprehensive Analysis of a Large Multicenter Registry
Authors' conclusion
Survival of DLG-SAS is better than that of HG-SAS and worse than that of MAS patients. At comparable MG, the lower the AVAi, the worse the prognosis, whereas at comparable AVAi, the higher the MG, the worse the prognosis.
Study context
- Population
- Consecutive patients with AS, BEL-F-ASt (Belgium-France) registry1,812 unoperated
- Participants
- 2,582 patients
- Exposure
- DLG-SAS vs moderate aortic stenosis (MAS) vs HG-SAS
- Outcome
- Survival
- Follow-up
- 5 years
Methodological detailsinverse probability weighting, propensity-score matched, consecutive patients
- Inverse probability weighting
- Propensity-score matched
- Consecutive patients
Main finding
As reported in the abstract
5-year survival
P < 0.001
Observational data: associations, not effects.
Further findings
5-year survival in unoperated patients (MAS vs DLG-SAS vs HG-SAS)
- Similar results in unoperated patients: MAS vs DLG-SAS vs HG-SAS
- 54.1% vs 37.9% vs 28.1%, P < 0.001
- Unoperated n = 1,812
Survival, propensity score-matched for MG: MAS vs DLG-SAS
- Survival better in MAS than in DLG-SAS
- 52% vs 40%, P < 0.001
- Propensity score-matched
Survival, propensity score-matched for AVAi: DLG-SAS vs HG-SAS
- Survival better in DLG-SAS than in HG-SAS
- 45% vs 33%, P < 0.001
- Propensity score-matched
Original publication
Prognostic Implications of Discordant Low-Gradient Severe Aortic Stenosis: Comprehensive Analysis of a Large Multicenter Registry. JACC Adv. Published 22 February 2023. doi:10.
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