Valvular & structural heart disease
Isolated Functional Tricuspid Regurgitation: How to Define Patients at Risk for Event?
Authors' conclusion
RAVI and TAPSE/sPAP are relevant for predicting the risk for event at 2 year follow-up in patients with an isolated functional TR.
Study context
- Population
- Patients with significant functional tricuspid regurgitation (TR) (effective regurgitant orifice area > 30 mm²) and LVEF > 40%
- Participants
- 160 patients
- Exposure
- Patients with events vs event-free patients
- Eventn = 56
- Outcome
- All-cause death or hospitalization for HF
- Follow-up
- 2 years
Methodological detailsmulticentre, French
- Multicentre
- French
Main finding
As reported in the abstract
Event
35%
56
Observational data: associations, not effects.
Further findings
Multivariable prognostic model
| OR (95% CI) | ||
|---|---|---|
| TAPSE/sPAP ratio > 0.4 | 0.41 (0.2–0.82) | |
| RAVI > 60 mL/m² | 2.13 (0.96–4.75) | |
| 0.20.5125Odds ratio (log scale) |
| Outcome | Event | Event-free | P value |
|---|---|---|---|
| Baseline RAVI and TAPSE/sPAP ratioBoth RAVI and TAPSE/sPAP | P < 0.05 | ||
| RAVI | 73 mL/m² | 64.7 mL/m² | |
| TAPSE/sPAP | 0.40 | 0.50 |
Baseline right atrial volume index (RAVI) and TAPSE/sPAP ratio
- More advanced right heart remodelling at baseline in event group, but similar TR severity
Group × time interaction of clinical and imaging parameters
- None had a significant group × time interaction
Original publication
Isolated Functional Tricuspid Regurgitation: How to Define Patients at Risk for Event? ESC Heart Fail. Published 21 February 2023. doi:10.
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