Coronary disease & ACS

Prognostic Role of Early Cardiac Magnetic Resonance in Myocardial Infarction With Nonobstructive Coronary Arteries

JACC Cardiovasc ImagingPublished Prospective cohort study

Authors' conclusion

In MINOCA with early CMR execution, the %LGE and abnormal T2 mapping values were identified as independent predictors of adverse cardiac events at ∼3.0 years of follow-up.

Study context

Population
Myocardial infarction with nonobstructive coronary arteries (MINOCA) patients with early cardiac magnetic resonance (CMR), excluding acute myocarditis, takotsubo, cardiomyopathies and other nonischemic etiologies, January 2017 to October 2021437 assessed
Participants
198 patients
Exposure
CMR phenotypes: Late gadolinium enhancement (LGE)+/M+ vs LGE-/M+ vs LGE-/M-
  • LGE+/M+n = 116
Outcome
MACE
Follow-up
Mean 33.7 ± 12.0 months
Methodological detailsCMR performed on average 4.8 ± 1.5 days from acute presentation
  • CMR performed on average 4.8 ± 1.5 days from acute presentation

Main finding

As reported in the abstract

Observational data: associations, not effects.

Further findings

Independent predictors of major adverse cardiovascular events (MACE) (multivariable Cox regression)

HR (95% CI)P value
%LGE1.123 (1.064–1.185)P < 0.001
T2 mapping values1.190 (1.145–1.237)P = 0.001
Extension of myocardial damage at CMR significantly greater in patients who developed MACE

Original publication

Prognostic Role of Early Cardiac Magnetic Resonance in Myocardial Infarction With Nonobstructive Coronary Arteries. JACC Cardiovasc Imaging. Published 19 July 2023. doi:10.1016/j.jcmg.2023.05.016

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