Pulmonary vascular disease & thromboembolism
Prognostic Role of Pulmonary Impedance Estimation to Predict Right Ventricular Dysfunction in Pulmonary Hypertension
Authors' conclusion
Raised pulmonary Zc was independent of elevated mPAP in patients with PH and more strongly predictive of maladaptive RV remodelling than PVR and mPAP.
Study context
- Population
- Clinically indicated patients referred for same-day cardiac magnetic resonance (CMR) and right heart catheterization (60 ± 16 years; 77% females)
- Participants
- 70 participants
- Exposure
- Pulmonary Zc by pulmonary hypertension (PH) classification
- mPAP <25 mmHgn = 16reference
- PrecPHn = 24
- IpcPHn = 15
- CpcPHn = 15
- Outcome
- Pulmonary impedance (Zc) by PH classification
Methodological detailssame-day CMR and right heart catheterization
- Same-day CMR and right heart catheterization
Main finding
As reported in the abstract
Pulmonary Zc
- Difference in pulmonary Zc between mPAP<25 mmHg patients and those with PH
- P = 0.05
Observational data: associations, not effects.
Further findings
mPAP and PVR, mPAP<25 mmHg vs PH
- Significant difference in mPAP
- P < 0.001
- Significant difference in PVR
- P = 0.001
Association of elevated mPAP with PVR and pulmonary Zc (all PH)
- Elevated mPAP associated with raised PVR
- P < 0.001
- Elevated mPAP not associated with pulmonary Zc
- P = 0.87
- Except PrecPH: mPAP associated with pulmonary Zc
- P < 0.001
Right ventricular (RV) function (RVSWI, RVEF, CO)
- Elevated pulmonary Zc associated with reduced RVSWI, RVEF and CO; PVR and mPAP were not
- all P < 0.05
Original publication
Prognostic Role of Pulmonary Impedance Estimation to Predict Right Ventricular Dysfunction in Pulmonary Hypertension. ESC Heart Fail. Published 10 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →