Acute cardiac care & resuscitation
Prognostic significance of haemodynamic parameters in patients with cardiogenic shock
An erratum to this article was published (Eur Heart J Acute Cardiovasc Care, 24 Jul 2024 ↗)
Authors' conclusion
In a contemporary CS population, presenting haemodynamic parameters reflecting decreased systemic arterial tone and right ventricular dysfunction are associated with adverse outcomes and systemic hypoperfusion.
Study context
- Population
- Patients with cardiogenic shock in North American cardiac ICUs with invasive haemodynamic assessment within 24 h of admission, 2018–2022of 3603 cardiogenic shock (CS) admissions
- Participants
- 1,473 patients
- Outcome
- In-hospital mortality
Methodological detailsmulticentre, investigator-initiated, Critical Care Cardiology Trials Network registry coordinated by the TIMI Study Group
- Multicentre
- Investigator-initiated
- Critical Care Cardiology Trials Network registry coordinated by the TIMI Study Group
Main finding
As reported in the abstract
- Parameters associated with mortality: low mean arterial pressure (MAP), low SBP, low systemic vascular resistance, elevated right atrial pressure (RAP), elevated RAP/PCWP ratio, low pulmonary artery pulsatility index
Observational data: associations, not effects.
Further findings
Presenting haemodynamics
- Median cardiac index (25th-75th percentile) L/min/m²
- 1.9 (1.6-2.4)
- MAP (mmHg)
- 74 (66-86)
Sensitivity analyses (excluding temporary MCS; adjusted for vasoactive-inotropic score)
- Associations generally consistent when controlling for background pharmacologic and mechanical support
Presenting serum lactate
- Same parameters associated with higher presenting serum lactate
Original publication
Prognostic significance of haemodynamic parameters in patients with cardiogenic shock. Eur Heart J Acute Cardiovasc Care. Published 28 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →