Prognostic Significance of Hemodynamics in Patients With Transposition of the Great Arteries and Systemic Right Ventricle
Authors' conclusion
A low aortic pulsatility index (<1.5) and the cold/wet hemodynamic profile are linked with an elevated risk of adverse long-term cardiac outcomes in patients with TGA and systemic right ventricle.
Study context
- Population
- Adults with TGA and systemic RV who underwent cardiac catheterization, 1994–2020of 1721 with TGA
- Participants
- 242 adults
- Exposure
- Invasive haemodynamic parameters and profiles
- Outcome
- Composite of:
- All-cause death
- Heart transplantation
- Mechanical circulatory support
- Follow-up
- Median 11.4 (IQR 7.5-15.9) years
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Adjusted hazard ratio (95% CI)P value
Aortic pulsatility index <1.5
5.90(3.01–11.62)
P < 0.001Cold/wethighest risk of the 4 hemodynamic profiles
3.83(1.63–9.02)
P < 0.001Observational data: associations, not effects.
Original publication
Prognostic Significance of Hemodynamics in Patients With Transposition of the Great Arteries and Systemic Right Ventricle. Circ Heart Fail. Published 29 August 2024. doi:10.
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