Sex-Related Differences and Influence of Pregnancy in Transposition of Great Arteries With Systemic Right Ventricle
Authors' conclusion
Women with a sRV-biV have fewer adverse cardiovascular events than men. Due to sRV-biV, pregnancy remains with high maternal risk but is not associated with worse long-term cardiac outcomes under rigorous multidisciplinary cardio-obstetrical care.
Study context
- Population
- Adults with TGA with a systemic RV and biventricular physiology (sRV-biV), age 42.6 ± 12.8 years82 (38.4%) women
- Participants
- 213 adults
- Exposure
- Women vs men; women with vs without pregnancies resulting in live births
- Womenn = 82
- Women with pregnanciesn = 47
- Women without pregnanciesn = 32reference
- Outcome
- Cardiac events, interventions, last follow-up sRV-biV dysfunction and HF medications
- Follow-up
- Median 16 years
Main finding
As reported in the abstract
Cardiac outcomes, women vs men
Men vs WomenHazard ratio (95% CI)P value
Nonsustained VT; lower incidence in women; univariable analysis
1.80(1.04–3.09)
P = 0.035HF-related hospitalizations; nonsignificantly fewer in women; univariable analysis
2.10(0.95–4.67)
P = 0.069- Lower prevalence of moderate to severe sRV-biV dysfunction in women at last follow-up
- P < 0.001
- Fewer ICDs for primary prevention in women
- P = 0.016
Observational data: associations, not effects.
Further findings
Cardiac events after pregnancy, women with vs without pregnancies · 15 (IQR: 9-28) years following pregnancy
- High prevalence of cardiac events after pregnancy, no significant differences vs women without pregnancies
Original publication
Sex-Related Differences and Influence of Pregnancy in Transposition of Great Arteries With Systemic Right Ventricle. JACC Adv. Published 12 June 2024. doi:10.
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