Pulmonary vascular disease & thromboembolism
Differential effects of balloon pulmonary angioplasty on chronic thromboembolic pulmonary disease
Authors' conclusion
BPA was associated with an improvement in the haemodynamic status and exercise tolerance in patients with CTEPH even with low DLco. However, low DLco may attenuate the effect of BPA on mPAP and pulmonary vascular resistance and require more treatment sessions.
Study context
- Population
- Patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH) who underwent balloon pulmonary angioplasty (BPA) at the University of Tokyo Hospital, July 2011 to August 2023
- Participants
- 75 patients
- Exposure
- Low DLco vs normal DLco in patients undergoing BPA
- Low DLco (LD)n = 36
- Outcome
- mPAP after BPA
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Sβ
−0.304
95% CI −7.015 to −1.132P = 0.007
Mean pulmonary artery pressure (mPAP); ANCOVA adjusted for baseline values
Sβ
−0.324
95% CI −141.0 to −29.81P = 0.003
pulmonary vascular resistance; ANCOVA adjusted for baseline values
Observational data: associations, not effects.
Further findings
Baseline 6-minute walking distance (before BPA)
Baseline mPAP (before BPA)
Median
| Outcome | ND | LD |
|---|---|---|
| Number of BPA sessions | 4 | 6 |
Baseline mPAP (before BPA)
- Baseline mPAP similar
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →