Prognostic value of a novel artificial intelligence-based coronary computed tomography angiography-derived ischaemia algorithm for patients with suspected coronary artery disease
Main finding · Covariates: age/sex/hypertension/diabetes/smoking/typical anginaResult — go to the resultAdjusted hazard ratio 1.96 95% CI 1.46–2.63Authors' conclusion
Amongst patients with suspected CAD, an abnormal AI-QCTischaemia result was associated with a two-fold increased adjusted rate of long-term death, MI, or uAP.
Study context
- Population
- Symptomatic patients with suspected coronary artery disease (CAD) undergoing coronary computed tomography angiography (CTA)1,880 with conclusive result
- Participants
- 2,271 patients
- Exposure
- Abnormal vs normal AI-QCTischaemia result
- Abnormal AI-QCTischaemian = 509/1,880
- Normal AI-QCTischaemian = 1,371/1,880reference
- Outcome
- Composite of:
- Death
- Myocardial infarction (MI)
- Unstable angina pectoris
- Follow-up
- Median 6.9 years
Methodological detailsblinded analysts
- Blinded analysts
Main finding
As reported in the abstract
Covariates: age/sex/hypertension/diabetes/smoking/typical angina
Adjusted hazard ratio
1.96
95% CI 1.46–2.63
P < 0.001
Abnormal AI-QCTischaemiavs Normal AI-QCTischaemia
adjusted HR 1.96 (95% CI 1.46–2.63); P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted HR (95% CI) | P value | |
|---|---|---|---|
| Primary endpoint, by CAD severity (subgroup)Abnormal AI-QCTischaemiavs Normal AI-QCTischaemiaNo/non-obstructive CAD (n = 1373/1847) | 1.81 (1.09–3.00) | P = 0.022 | |
| Primary endpoint, by CAD severity (subgroup)Abnormal AI-QCTischaemiavs Normal AI-QCTischaemiaObstructive CAD (n = 474/1847) | 1.26 (0.75–2.12) | P = 0.386 | |
| 0.20.5125Adjusted hazard ratio (log scale) |
- Primary endpoint, by CAD severity (subgroup): P-interaction = 0.032
Original publication
Prognostic value of a novel artificial intelligence-based coronary computed tomography angiography-derived ischaemia algorithm for patients with suspected coronary artery disease. Eur Heart J Cardiovasc Imaging. Published 12 December 2023. doi:10.
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