Stress Ulcer Prophylaxis in Mechanically Ventilated Patients With Acute Myocardial Infarction
Main findingResult — go to the resultOdds ratio 0.97 95% CI 0.89–1.06Authors' conclusion
Among patients with AMI requiring IMV in this observation cohort study, there was no difference in mortality among patients receiving H2Bs vs PPIs for stress ulcer prophylaxis despite fewer ventilator days and lower ventilator-associated pneumonia in those receiving H2Bs.
Study context
- Population
- Adults with acute myocardial infarction (AMI) requiring invasive mechanical ventilation, Vizient Clinical Data Base, October 2015–December 2019
- Participants
- 11,252 adults
- Exposure
- H2Bs vs proton pump inhibitors (PPIs) for stress ulcer prophylaxis
- H2Bsn = 3,748
- PPIsn = 7,504reference
- Outcome
- In-hospital mortality
Methodological detailsmultivariable logistic regression
- Multivariable logistic regression
Main finding
As reported in the abstract
Odds ratio
0.97
95% CI 0.89–1.06
P = 0.49
By group
H2Bsvs PPIs
OR 0.97 (95% CI 0.89–1.06); P = 0.49
Observational data: associations, not effects.
Further findings
- H2Bs associated with fewer ventilator days, less ventilator-associated pneumonia and lower hospitalization cost (unadjusted and adjusted)
Safety
Clostridium difficile infections
- Similar C difficile infections with H2Bs vs PPIs
Original publication
Stress Ulcer Prophylaxis in Mechanically Ventilated Patients With Acute Myocardial Infarction. JACC Adv. Published 6 December 2023. doi:10.
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