Heart failure & cardiomyopathies
Prognostic Value of a Multi-mRNA Signature for 1-Year All-Cause Death in Hospitalized Patients With Heart Failure With a Preserved Ejection Fraction
Authors' conclusion
The 5-mRNA signature is a promising predictive tool for 1-year all-cause death and shows improved prognostic power over the established risk scores and NT-proBNP in patients with heart failure with preserved ejection fraction.
Study context
- Population
- Hospitalized patients with HFpEF
- Comparison
- 5-mRNA signature vs reference model
- Test setn = 171
- Validation setn = 120
- Outcome
- All-cause death
- Follow-up
- 1 year
Methodological detailsdiscovery, test and validation sets, mRNA microarrays
- Discovery, test and validation sets
- mRNA microarrays
Performance
As reported in the abstract
1-year all-cause death, by 5-mRNA signature scores
5-mRNA signatureHazard ratio (95% CI)P value
Test set
2.72(1.98–3.74)
P < 0.001Validation set
3.95(2.40–6.48)
P < 0.001Further findings
| Outcome | Test set | Validation set |
|---|---|---|
| Discrimination: 5-mRNA signature vs reference model (AUC) | ||
| AUC reference model | 0.696 | 0.712 |
| AUC 5-mRNA signature | 0.813 | 0.848 |
| Discrimination: composite model (5-mRNA score + reference model variables) | ||
| AUC (95% CI) | 0.861 (0.784-0.939) | 0.859 (0.755-0.963) |
Reclassification: composite vs reference model (NRI and IDI)
- Composite model significantly improved patient classification vs reference model in both sets
- P < 0.001
Original publication
Prognostic Value of a Multi-mRNA Signature for 1-Year All-Cause Death in Hospitalized Patients With Heart Failure With a Preserved Ejection Fraction. Circ Heart Fail. Published 7 June 2024. doi:10.
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