Loop diuretic therapy with or without heart failure: impact on prognosis

Eur Heart JPublished 7 Jun 2024

Authors' conclusion

Mortality is more strongly associated with loop diuretic use than with a record of heart failure.

Study context

Population: Adults with CVD or taking loop diuretics, Glasgow regional health records, 2009–16
Participants: 198,898 adults

Exposure: Loop diuretic use and/or HF record vs neither
referencen = 161,935reference
loop diuretics with no record of heart failuren = 23,963
heart failure treated with loop diureticsn = 7,844
heart failure in the absence of loop diureticsn = 5,156
Outcome: All-cause mortality
Follow-up: 5 years

As reported in the abstract

5-year mortality

HF without loop diuretics22%

Loop diuretics, no HF40%

HF with loop diuretics52%

Adjusted hazard ratio (95% CI)

HF without loop diuretics vs Neither

1.2(1.1–1.3)

Loop diuretics, no HF vs Neither

1.8(1.7–1.8)

HF with loop diuretics vs Neither

2.2(2.0–2.2)

Observational data: associations, not effects.

Loop diuretic therapy with or without heart failure: impact on prognosis. Eur Heart J. Published 7 June 2024. doi:10.1093/eurheartj/ehae345

Summarised from the published abstract; every number is checked against it