Heart failure & cardiomyopathies
Prognostic Value of Advanced Lung Cancer Inflammation Index in Heart Failure Patients: A Comprehensive Analysis
Authors' conclusion
ALI is associated with all-cause and cardiovascular mortality risk and structural changes in the heart in patients with HF.
Study context
- Population
- Patients with heart failure (HF) (National Health and Nutrition Examination Survey (NHANES); and HF patients undergoing CMR)Study 1 n = 1359
- Exposure
- Higher vs lower advanced lung cancer inflammation index
- Outcome
- All-cause and CV mortality (Study 1); LV reverse remodelling (Study 2)
Methodological detailsNHANES 1999–2018 (Study 1), CMR cohort 2020–2023 (Study 2)
- NHANES 1999–2018 (Study 1)
- CMR cohort 2020–2023 (Study 2)
Main finding
As reported in the abstract
Elevated ALIHazard ratio (95% CI)P value
All-cause mortality; multivariable adjusted
0.58(0.42–0.79)
P < 0.001CV mortality; multivariable adjusted
0.61(0.38–0.97)
P = 0.036- Deaths: all-cause
- 699
- Deaths: CV
- 293
- Linear negative association with CV mortality, P for nonlinear
- 0.5198
- Linear negative association with all-cause mortality, P for nonlinear
- 0.3993
Observational data: associations, not effects.
Further findings
LV reverse remodelling after discharge, high ALI (Study 2, n = 79)
| OR (95% CI) | P value | ||
|---|---|---|---|
| High ALIAdjusted multivariable logistic regression | 3.16 (1.06–10.8) | P = 0.049 | |
| 0.050.21520Odds ratio (log scale) |
All-cause mortality: prediction by ALI (time-dependent ROC), Study 1
- AUC at 3 years
- 0.678
- AUC at 5 years
- 0.674
- AUC at 10 years
- 0.683
CV mortality: prediction by ALI (time-dependent ROC), Study 1
- AUC at 3 years
- 0.694
- AUC at 5 years
- 0.685
- AUC at 10 years
- 0.697
Dose-response of ALI with mortality (restricted cubic spline (RCS)), Study 1
- Linear negative correlation, all-cause mortality
- P for nonlinear = 0.3993
- Linear negative correlation, CV mortality
- P for nonlinear = 0.5198
Correlation of ALI with extracellular volume (Study 2)
- Spearman r
- −0.25
- P
- P = 0.023
Original publication
Prognostic Value of Advanced Lung Cancer Inflammation Index in Heart Failure Patients: A Comprehensive Analysis. ESC Heart Fail. Published 3 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →