Heart failure & cardiomyopathies
Prognostic Utility of Advanced Lung Cancer Inflammation Index in Heart Failure with Preserved Ejection Fraction
Authors' conclusion
Low ALI levels were significantly associated with poor prognosis in elderly multimorbid HFpEF patients.
Study context
- Population
- Elderly multimorbid patients with acute decompensated heart failure (HF) and LVEF ≥50% (HF with preserved ejection fraction (HFpEF)), PURSUIT-HFpEF registry1,121 analysed
- Participants
- 1,238 patients
- Outcome
- All-cause death
Methodological detailsmulticentre, observational, ALI (BMI × serum albumin / neutrophil-to-lymphocyte ratio) calculated from discharge data
- Multicentre
- Observational
- ALI (BMI × serum albumin / neutrophil-to-lymphocyte ratio) calculated from discharge data
Main finding
As reported in the abstract
All-cause death, by ALI (log-transformed)
Adjusted HR for log-transformed ALI (multivariable Cox model), 95% CI 0.34-0.75, P = 0.001
0.50
Observational data: associations, not effects.
Further findings
Incremental prognostic value of ALI added to MAGGIC risk score
- Net reclassification improvement (NRI) (95% CI 28%-65%), P < 0.001
- 46%
- Integrated discrimination improvement (IDI) (95% CI 2.8%-6.5%), P < 0.001
- 4.6%
Incremental prognostic value of ALI added to geriatric nutritional risk index
- NRI (95% CI −3% to 35%), P = 0.103
- 16%
- IDI (95% CI 0.8%-3.1%), P < 0.001
- 2.0%
Incremental prognostic value of ALI added to C-reactive protein
- NRI (95% CI 20%-58%), P < 0.001
- 39%
- IDI (95% CI 2.9%-6.6%), P < 0.001
- 4.8%
Original publication
Prognostic Utility of Advanced Lung Cancer Inflammation Index in Heart Failure with Preserved Ejection Fraction. ESC Heart Fail. Published 2 July 2025. doi:10.
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