Arrhythmias & electrophysiologyCohort study
Influenza vaccination, incident atrial fibrillation, and cardiovascular outcomes
- Retrospective cohort study
- target-trial emulation
- propensity-score matched (1:1, 65 baseline variables)
Authors' conclusion
In a large retrospective observational real-world cohort, influenza vaccination was associated with lower risks of incident AF and multiple cardiovascular outcomes.
Study context
- Population
- Adults with a routine healthcare visit in 2022, TriNetX Global Collaborative Federated Research Data Networkafter matching
- Participants
- 276,888 adults
- Exposure
- Influenza vaccination vs no recorded vaccination
- Vaccinatedn = 138,444
- Non-vaccinatedn = 138,444reference
- Outcome
- Incident atrial fibrillation (AF)
- Follow-up
- Mean 2.7 ± 0.7 years
Main finding
As reported in the abstract
Hazard ratio
0.80
95% CI 0.76–0.84
P < 0.0001
By group
Vaccinated vs Non-vaccinated
HR 0.80 (95% CI 0.76–0.84); P < 0.0001
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| All-cause mortality, MI, incident HF, CV-related hospitalization — Vaccinated vs Non-vaccinated · all-cause mortality | 0.85 (0.82–0.89) | |
| All-cause mortality, MI, incident HF, CV-related hospitalization — Vaccinated vs Non-vaccinated · MI | 0.91 (0.86–0.97) | |
| All-cause mortality, MI, incident HF, CV-related hospitalization — Vaccinated vs Non-vaccinated · incident HF | 0.92 (0.88–0.96) | |
| All-cause mortality, MI, incident HF, CV-related hospitalization — Vaccinated vs Non-vaccinated · CV-related hospitalization | 0.97 (0.95–0.99) | |
| 0.512Hazard ratio (log scale) |
Age and CVD subgroups
- Associations directionally consistent across subgroups, without significant effect modification
Original publication
Influenza vaccination, incident atrial fibrillation, and cardiovascular outcomes. Eur Heart J. Published 11 July 2026. doi:10.1093/eurheartj/ehag543
Summarised from the published abstract; every number is checked against it