Heart failure & cardiomyopathies
Prognostic Value of Hemodynamic Gain Index in Patients With Heart Failure With Reduced Ejection Fraction
Authors' conclusion
HGI and peak RPP show good correlation with peak Vo2 in terms of prognostication and outcome discrimination in patients with HFrEF and may serve as suitable alternatives to CPET-derived prognostic variables.
Study context
- Population
- Patients with chronic heart failure with reduced ejection fraction (HFrEF) who underwent cardiopulmonary exercise testing (CPET), December 2012 to September 2020954 analysed
- Participants
- 1,067 patients
- Exposure
- Nonmetabolic exercise testing parameters vs peak Vo2 for prognosis
- Outcome
- Composite of:
- All-cause mortality
- LV assist device implantation
- Heart transplantation
- Follow-up
- Median 946 days
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
Primary composite outcome
Hemodynamic gain index (HGI)
0.69
95% CI 0.65–0.72
AUC
Peak rate-pressure product (RPP)
0.71
95% CI 0.68–0.74
AUC
Peak Vo2
0.70
95% CI 0.66–0.73
AUC
Each group vs peak Vo2Adjusted HR per doubling (95% CI)P value
HGI
0.76(0.67–0.87)
P < 0.001Peak RPP
0.36(0.28–0.47)
P < 0.001- Primary outcome events
- 331 of 954 patients (34.7%)
Observational data: associations, not effects.
Original publication
Prognostic Value of Hemodynamic Gain Index in Patients With Heart Failure With Reduced Ejection Fraction. JACC Heart Fail. Published 14 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →