Heart failure & cardiomyopathies
Prognostic value of left atrioventricular coupling index in heart failure
Authors' conclusion
In patients with HF and LVEF <50%, LACI is independently associated with adverse events. Patients with most impaired left atrioventricular coupling have the worst clinical outcomes.
Study context
- Population
- Patients with HF and left ventricular ejection fraction (LVEF) < 50% undergoing cardiac magnetic resonance; patients with atrial fibrillation or flutter excludedmean age 62 ± 12 years, 78% male
- Participants
- 478 patients
- Exposure
- Patients within the worst left atrioventricular coupling index (LACI) tertile (≥30.9%) as compared with patients in the first or second tertile
- Outcome
- LACI distribution
Methodological detailspatients divided according to LACI tertiles
- Patients divided according to LACI tertiles
Main finding
As reported in the abstract
Median LACI
27.1%
interquartile range 19.9–34.5
Observational data: associations, not effects.
Further findings
| Outcome | HR | P value |
|---|---|---|
| Combined endpoint of all-cause death or HF hospitalization · long-term follow-upLACI · unadjusted | 1.87 | P = 0.01 |
| Combined endpoint of all-cause death or HF hospitalization · long-term follow-upLACI | 1.77 | P = 0.02 |
| Combined endpoint by LACI tertileWorst LACI tertile vs First tertile | 1.69 | P = 0.02 |
| Combined endpoint by LACI tertileWorst LACI tertile vs Second tertile | 1.77 | P = 0.02 |
- Combined endpoint of all-cause death or HF hospitalization: adjusted for sex, age, ischaemic HF aetiology, LVEF, left atrial (LA) reservoir strain, diabetes mellitus, LV scar, mitral regurgitation, and LVEDVi
LV and LA volumes
- Worst LACI tertile showed smaller LV volumes and larger LA volumes than first or second tertile
Original publication
Prognostic value of left atrioventricular coupling index in heart failure. Eur Heart J Cardiovasc Imaging. Published 10 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →