Heart failure & cardiomyopathies
Cardiac Magnetic Resonance Left Atrioventricular Coupling Index as a Prognostic Tool in Hypertrophic Cardiomyopathy
Authors' conclusion
LACI is an independent risk factor for clinical adverse outcome and is superior to conventional LA parameters and LGE extent for the identification of high-risk HCM patients.
Study context
- Population
- Hypertrophic cardiomyopathy (HCM) patients who underwent cardiac magnetic resonance examinationHCM patients retrospectively enrolled
- Participants
- 206 participants
- Exposure
- Left atrioventricular coupling index (LACI) added to a clinical model vs left atrial (LA) diameter, LA ejection fraction (LAEF), LA volume index (LAVI) and late gadolinium enhancement (LGE) extent
- Outcome
- Composite endpoint:
- Death-related
- Heart failure-related
- Arrhythmia-related events
- Follow-up
- Median 60 [interquartile range (50-68)] months
Main finding
As reported in the abstract
- HCM patients reached the endpoint
- Thirty-four
Observational data: associations, not effects.
Further findings
LACI as predictor of composite events (multivariate Cox regression)
| Hazard ratio (95% CI) | P value | ||
|---|---|---|---|
| LACIAfter adjustment for age and atrial fibrillation · independent predictor | 1.054 (1.037–1.071) | P < 0.001 | |
| 0.512Hazard ratio (log scale) |
Optimal cut-off for LACI in risk stratification
- Optimal cut-off for LACI
- 40.09%
Discrimination of clinical model with LACI
- C-statistic
- 0.892 with 95% CI (0.861, 0.922)
- Net reclassification improvement (NRI)
- 0.627, 95% CI: 0.112-0.934
- Integrated discrimination improvement (IDI)
- 0.295, 95% CI: 0.016-0.709
- Compared with LA diameter, LAEF, LAVI and LGE extent
Original publication
Cardiac Magnetic Resonance Left Atrioventricular Coupling Index as a Prognostic Tool in Hypertrophic Cardiomyopathy. ESC Heart Fail. Published 4 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →