Heart failure & cardiomyopathies
Prognostic Value of Lipid Parameters Among Patients with Heart Failure: A Systematic Review and Meta-Analysis
Authors' conclusion
Higher levels of lipids parameters were associated with lower mortality in patients with HF. Lipid parameters may improve prognostication in predictive models for patients with HF. Because of the observational nature of included studies, no claims about the causal effect of changing lipid parameters can be made.
Study context
- Population
- Patients with heart failure (HF)
- Participants
- 93,286 patients52 studies
- Comparison
- Association of any of the four lipid parameters [total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglycerides] with mortality among patients with HF
- Outcome
- Mortality, univariable analysis
Methodological detailsrandom-effects model, QUIPS tool used to assess risk of bias
- Random-effects model
- QUIPS tool used to assess risk of bias
Pooled result
As reported in the abstract
HR/OR, per 10 mg/dL increment (95% CI)
TC
0.94(0.93–0.96)
HDL-C
0.89(0.80–0.99)
LDL-C
0.93(0.90–0.97)
Triglycerides
0.95(0.92–0.99)
Per 10 mg/dL increment, as printed
Further pooled results
| Outcome | HR/OR (per 10 mg/dL increment) (95% CI) | |
|---|---|---|
| Mortality, multivariable analysisTC | 0.95 (0.93–0.97) | |
| Mortality, multivariable analysisLDL-C | 0.94 (0.89–0.99) | |
| 0.512HR/OR (log scale) |
- Mortality, multivariable analysis: as printed: "lower levels of TC ... were associated with lower mortality"
- Mortality, multivariable analysis: as printed: "lower levels of ... LDL-C ... were associated with lower mortality"
Original publication
Prognostic Value of Lipid Parameters Among Patients with Heart Failure: A Systematic Review and Meta-Analysis. ESC Heart Fail. Published 24 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →