Heart failure & cardiomyopathies
Prognostic Value of Natriuretic Peptide Levels in Heart Failure With Recovered Ejection Fraction
Authors' conclusion
NT-proBNP is an independent and robust predictor of prognosis in patients with HF with recovered LVEF and may therefore be used to guide further optimization of pharmacotherapy.
Study context
- Population
- Patients with heart failure (HF) with recovered left ventricular ejection fraction (LVEF) (previous LVEF ≤40% improved to ≥50%), 2009–20247 NT-proBNP groups
- Participants
- 3,935 patients
- Exposure
- NT-proBNP groups at time of LVEF recovery
- Outcome
- LVEF relapse (LVEF decrease by ≥10% to <50%) and composite of HF hospitalization or all-cause death
Main finding
As reported in the abstract
Near-normal vs normal NT-proBNP: higher risk of LVEF relapse
46%
Near-normal vs normal NT-proBNP: higher risk of composite outcome
82%
Observational data: associations, not effects.
Further findings
NT-proBNP at time of LVEF recovery
- Median NT-proBNP at LVEF recovery 1341 pg/mL (IQR 400-4207)
Effect modification by subgroup
- Relationship consistent across age, sex, AF status and renal function; modified by BMI, with higher BMI associated with higher risk
Composite outcome in patients with sustained LVEF recovery (no LVEF relapse)
- NT-proBNP predictive of the composite outcome even without LVEF relapse
Original publication
Prognostic Value of Natriuretic Peptide Levels in Heart Failure With Recovered Ejection Fraction. Circ Heart Fail. Published 3 November 2025. doi:10.
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