Heart failure & cardiomyopathies
Prognostic Value of Growth Differentiation Factors 15 in Acute Heart Failure Patients with Preserved Ejection Fraction
Main finding · 1-year HF readmissionResult — go to the resultHazard ratio 2.25 95% CI 1.43–3.54Authors' conclusion
In hospitalized patients with HFpEF, GDF-15 measured within 48 h of admission is a strong independent biomarker for 1 year HF readmission and even better than NT-proBNP. GDF-15 combined with the traditional indicators provided incremental prognostic value in this population.
Study context
- Population
- Patients hospitalised for acute onset of HF with preserved ejection fraction (HFpEF), Chinese cohort
- Participants
- 380 patients
- Exposure
- GDF-15 tertiles; GDF-15 vs N-terminal pro-brain natriuretic peptide (NT-proBNP) for prognosis
- Outcome
- All-cause death and HF readmission
- Follow-up
- 1 year
Main finding
1-year HF readmission
Hazard ratio
2.25
95% CI 1.43–3.54
P < 0.001
As reported in the abstract
- Trend across tertiles, 1-year heart failure (HF) readmission
- P < 0.001
- Trend across tertiles, 1-year all-cause death
- P = 0.004
Observational data: associations, not effects.
Further findings
Discrimination (c-statistic), univariate Cox: GDF-15 vs NT-proBNP · 1 year
- GDF-15, HF readmission
- 0.632
- GDF-15, all-cause death
- 0.644
- NT-proBNP, HF readmission
- 0.595
- NT-proBNP, all-cause death
- 0.610
Incremental value of adding GDF-15 to adjusted model (c-statistic) · 1 year
- HF readmission: 0.643 to 0.657
- All-cause death: 0.638 to 0.660
Correlates of GDF-15 (multivariate linear regression)
- Negative correlation with haemoglobin
- P = 0.01
- Positive correlation with creatinine
- P = 0.01
- Positive correlation with alanine transaminase
- P = 0.001
- Positive correlation with aldosterone antagonist therapy
- P = 0.018
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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