Heart failure & cardiomyopathies
Prognostic Value of Pericoronary Fat Attenuation Index on Computed Tomography for Hospitalization for Heart Failure
Authors' conclusion
LAD- and left circumflex artery-FAI can predict hospitalization for HFpEF in patients undergoing clinically indicated CCTA. Pericoronary inflammation may be useful for identifying patients at high risk of developing HFpEF.
Study context
- Population
- Patients who underwent clinically indicated coronary computed tomography angiography (CCTA) and transthoracic echocardiography
- Participants
- 1,196 consecutive patients
- Exposure
- Groups based on the optimal cutoff value for predicting hospitalization for heart failure with preserved ejection fraction (HFpEF) by receiver operating characteristic curve analysis
- Outcome
- Incidence of hospitalization for HFpEF
- Follow-up
- Median 4.3 years
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
Hazard ratio (95% CI)
LAD-FAI ≥−63.4 HU
4.8(2.1–10.8)
Left circumflex artery-FAI ≥−61.6 HU
4.5(2.1–9.4)
- Hospitalizations for HFpEF
- 29
Observational data: associations, not effects.
Further findings
C-statistic for predicting hospitalization for HFpEF with addition of LAD-FAI >−63.4 HU to a model with hypertension, estimated glomerular filtration rate <60 mL/min/1.73 m², and significant stenosis on CCTA
- C-statistic without LAD-FAI
- 0.646
- C-statistic with LAD-FAI
- 0.750
- P = 0.010
Original publication
Prognostic Value of Pericoronary Fat Attenuation Index on Computed Tomography for Hospitalization for Heart Failure. JACC Adv. Published 25 April 2025. doi:10.
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