Heart failure & cardiomyopathies
Prognostic value of plasma big endothelin-1 in patients with light chain cardiac amyloidosis
Main finding · All-cause mortalityResult — go to the resultHazard ratio 1.91 95% CI 1.05–3.49Authors' conclusion
Big ET-1 is a strong and independent predictor of mortality in patients with moderate to severe AL-CA
Study context
- Population
- Newly diagnosed AL-CA, modified Mayo 2004 stage II or III57 stage II, 34 IIIa, 50 IIIb
- Participants
- 141 participants
- Exposure
- Big ET-1 >0.88 pmol/L vs ≤0.88 pmol/L
- Outcome
- All-cause mortality
- Follow-up
- Median 25.7 months
Methodological detailsvalidation cohort
- Validation cohort
Main finding
As reported in the abstract
Hazard ratio
1.91
95% CI 1.05–3.49
P = 0.035
By group
Higher big ET-1
HR 1.91 (95% CI 1.05–3.49); P = 0.035
- Deaths
- 84 (59.6%)
Observational data: associations, not effects.
Secondary outcomes
Incremental prognostic value over modified Mayo 2004 stage
- C-index from 0.671 to 0.696
- P = 0.025
- Integrated discrimination improvement 0.168
- P = 0.047
Original publication
Prognostic value of plasma big endothelin-1 in patients with light chain cardiac amyloidosis. Heart. Published 30 July 2024. doi:10.
Summarised from the published abstract; every number is checked against it