Heart failure & cardiomyopathies
Prognostic value of pulmonary transit time by cardiovascular MRI in heart failure with preserved ejection fraction
Authors' conclusion
Prolonged PTT is an independent predictor of death or heart failure hospitalisation in HFpEF. As an easily obtainable and integrative CMR biomarker of cardiopulmonary haemodynamics, PTT may improve risk stratification in HFpEF, although its clinical application requires further investigation.
Study context
- Population
- Adult patients with heart failure with preserved ejection fraction (HFpEF)HFpEF patients studied, median follow-up 7.7 years
- Participants
- 118 patients
- Exposure
- Prolonged pulmonary transit time (PTT) and the composite outcome
- Outcome
- Composite of:
- Heart failure hospitalisation
- All-cause mortality
- Follow-up
- Median 7.7 years
Methodological detailsmultiparametric cardiovascular magnetic resonance (CMR), Multivariable Cox proportional hazard regression
- Multiparametric CMR
- Multivariable Cox proportional hazard regression
Main finding
As reported in the abstract
Prolonged PTTHazard ratio (CI)P value
Clinical model
2.222(1.222–4.041)
P = 0.009Blood biomarker model
1.776(1.022–3.087)
P = 0.042Imaging model
2.108(1.115–3.983)
P = 0.020Combined model incorporating the strongest markers
2.989(1.612–5.543)
P < 0.001- Composite events
- Eighty-one
- Heart failure hospitalisations
- 50
- Deaths
- 31
Observational data: associations, not effects.
Original publication
Prognostic value of pulmonary transit time by cardiovascular MRI in heart failure with preserved ejection fraction. Heart. Published 28 May 2026. doi:10.
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