Heart failure & cardiomyopathies
Prognostic Relevance and Lower Limit of the Reference Range of Left Ventricular Global Longitudinal Strain: A Clinical Validation Study
Authors' conclusion
This clinical validation study provides important clinical data concerning the LLN of GLS (identified and validated at 16%) and its prognostic relevance in the elderly and in asymptomatic ambulatory patients at risk for HF.
Study context
- Population
- Healthy adults (reference range); elderly subjects aged ≥80 years and asymptomatic ambulatory patients with preserved LVEF at risk for heart failure (HF) (prognosis)
- Participants
- 23,208 adults47 studies
- Comparison
- Global longitudinal strain (GLS) <16% vs GLS ≥16%
- Outcome
- LLN of LV GLS by 2D speckle-tracking echocardiography and its prognostic relevance for HF hospitalization
Pooled result
As reported in the abstract
LLN of GLS
LLN of GLS in meta-analysis (absolute value), across EchoPac, TomTec and QLab
16%
LLN of GLS in validation cohort (n = 2,217 healthy adults)
16%
Further pooled results
HF hospitalization with GLS <16%, asymptomatic ambulatory patients at risk for HF (n = 667) · within 6 years
| OR (95% CI) | ||
|---|---|---|
| GLS <16% | 5.1 (1.5–17.0) | |
| 0.050.21520Odds ratio (log scale) |
HF hospitalization with GLS <16%, elderly subjects (n = 159) · within 2 years
| OR (95% CI) | ||
|---|---|---|
| GLS <16% | 3.1 (1.1–8.8) | |
| 0.10.31310Odds ratio (log scale) |
Original publication
Prognostic Relevance and Lower Limit of the Reference Range of Left Ventricular Global Longitudinal Strain: A Clinical Validation Study. JACC Cardiovasc Imaging. Published 19 March 2025. doi:10.
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