Arrhythmias & electrophysiology
PROlonged posterior PERicardial chest tube treatment to reduce rates of postoperative atrial fibrillation following cardiac surgery (PROPER trial): Rationale and design of a prospective, multinational, randomized clinical trial
Study context
- Population
- Patients undergoing non-emergent, first-time coronary bypass grafting, aortic valve replacement, aortic surgery without circulatory arrest, or a combination of these proceduresplanned enrolment
- Participants
- 624 patients
- Planned comparison
- Prolonged drainage using a posterior pericardial chest tube vs standard care
- Primary endpoint
- Atrial fibrillation (AF) recorded within seven days after surgery
- Follow-up
- Within seven days after surgery
Methodological detailseight Nordic cardiac surgery centers, wearable electrocardiographic patch monitor in addition to routine surveillance, rationale and design (no results reported)
- Eight Nordic cardiac surgery centers
- Wearable electrocardiographic patch monitor in addition to routine surveillance
- Rationale and design (no results reported)
No results yet. This paper sets out the design of a trial; its results are to come.
Further findings
Secondary endpoints: Atrial fibrillation (AF) recurrence, hospitalization due to bleeding or ischemic stroke, and all-cause mortality · five years of follow-up
- Patients will be followed for five years.
Original publication
PROlonged posterior PERicardial chest tube treatment to reduce rates of postoperative atrial fibrillation following cardiac surgery (PROPER trial): Rationale and design of a prospective, multinational, randomized clinical trial. Am Heart J. Published 28 October 2026. doi:10.
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