PRospective evaluation of the European Society of Cardiology 0/1h-algorithm`s safety and efficacy for triage of patients with suspected myocardial infarction (PRESC1SE-MI): Rationale and design of a prospective international multicenter stepped-wedge cluster randomized controlled trial
Study context
- Population
- Consecutive adults with nontraumatic acute chest discomfort and suspected myocardial infarction (MI) presenting to the Emergency Department (ED)planned, at least
- Participants
- 52,156 adults
- Planned comparison
- European Society of Cardiology (ESC) 0/1h-algorithm vs ESC 0/3h-algorithm for triage of suspected MI
- Primary endpoint
- Co-primary: composite of type 1 MI or all-cause death (safety); length of stay in the ED (efficacy)
- Follow-up
- 30 days (safety)
Methodological detailsinternational, investigator-initiated, multicentre, stepped-wedge, cluster randomised, non-inferiority (safety) and superiority (efficacy), Power of at least 90%
- International
- Investigator-initiated
- Multicentre
- Stepped-wedge
- Cluster randomised
- Non-inferiority (safety) and superiority (efficacy)
- Power of at least 90%
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
PRospective evaluation of the European Society of Cardiology 0/1h-algorithm`s safety and efficacy for triage of patients with suspected myocardial infarction (PRESC1SE-MI): Rationale and design of a prospective international multicenter stepped-wedge cluster randomized controlled trial. Am Heart J. Published 31 October 2025. doi:10.
Summarised from the published abstract; every number is checked against it