Heart failure & cardiomyopathies
Proteomic Associations of NT-proBNP (N-Terminal Pro-B-Type Natriuretic Peptide) in Heart Failure With Preserved Ejection Fraction
Authors' conclusion
Circulating NT-proBNP levels exhibit prominent proteomic associations in HFpEF. Our findings suggest that higher NT-proBNP levels in HFpEF are a marker of fibrosis and inflammation.
Study context
- Population
- Patients with heart failure with preserved ejection fraction (HFpEF)4,928 proteins measured
- Participants
- 253 vs 218
- Comparison
- PHFS vs TOPCAT
- PHFSn = 253
- TOPCATn = 218
- Outcome
- Associations of SOMAScan-derived plasma NT-proBNP with levels of other proteins (robust linear regression, corrected for multiple comparisons)
Methodological details2 cohorts, aptamer-based proteomic assay (SOMAScan)
- 2 cohorts
- Aptamer-based proteomic assay (SOMAScan)
Main finding
As reported in the abstract
Proteins associated with NT-proBNP
| Group | SVEP1 β | ANGPT2 β |
|---|---|---|
| TOPCAT | 0.539 | 0.571 |
| PHFS | 0.516 | 0.459 |
SVEP1 β
TOPCAT0.539
PHFS0.516
ANGPT2 β
TOPCAT0.571
PHFS0.459
- SVEP1 and ANGPT2 associations, each cohort
- P < 0.0001
Further findings
Proteomic associations using NT-proBNP cut points of 360 pg/mL (480 pg/mL in AF)
- Similar proteomic associations
Original publication
Proteomic Associations of NT-proBNP (N-Terminal Pro-B-Type Natriuretic Peptide) in Heart Failure With Preserved Ejection Fraction. Circ Heart Fail. Published 1 February 2024. doi:10.
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