Arrhythmias & electrophysiology
Proteomic signatures for sudden cardiac death and related intermediate phenotypes
Performance · SCD per standard deviation increase in protein risk score (test set)Result — go to the resultHazard ratio 2.60 95% CI 2.12–3.18Authors' conclusion
A protein risk score derived from a single plasma sample significantly improved risk prediction of SCD and related intermediate phenotypes.
Study context
- Population
- General population individuals with plasma protein measurements from the UK Biobank Pharma Proteomics Projectindividuals with 1459 unique plasma protein measurements · Derivation (English centers) 40,722 · Validation (remaining centers) 11,983
- Participants
- 52,705 individuals
- Comparison
- Protein risk score added to sudden cardiac death (SCD) clinical risk factors vs SCD clinical risk factors alone
- Outcome
- SCD per standard deviation increase in protein risk score (test set)
Methodological detailsUK Biobank Pharma Proteomics Project, derivation at English centers, validation at remaining centers
- UK Biobank Pharma Proteomics Project
- Derivation at English centers, validation at remaining centers
Performance
As reported in the abstract
Hazard ratio
2.60
95% CI 2.12–3.18
Per standard deviation increase in protein risk score
hazard ratio 2.60 (95% CI 2.12–3.18)
Per standard deviation increase in protein risk, as printed
Further findings
Concordance index for SCD, protein risk score added to clinical risk factors
- Concordance index increase
- 0.063 (95% CI 0.037-0.105)
Concordance index for ventricular arrhythmia-mediated SCDs
- Increase in concordance index
- 0.070 (95% CI 0.010-0.188)
Risk reclassification · 10-year risk threshold of 5%
- Risk reclassification
- 16.9% (95% CI 9.0-24.7)
Intermediate phenotypes of SCD
- Significantly associated with corrected QT prolongation, an increase in left ventricular mean myocardial thickness, and a decrease in left ventricular global longitudinal strain
Protein risk score composition
- Unique plasma proteins in score
- 64
Original publication
Proteomic signatures for sudden cardiac death and related intermediate phenotypes. Heart Rhythm. Published 2 March 2026. doi:10.
Summarised from the published abstract; every number is checked against it