Heart failure & cardiomyopathies
Proteomics of Left Ventricular Structure in the Multi-Ethnic Study of Atherosclerosis
Authors' conclusion
We report proteomic profiling of LV size and geometry, which identified novel associations and reinforced previous findings on biomarker candidates for LV remodelling and HF.
Study context
- Population
- Diverse population-based cohort without known cardiovascular disease (CVD) (Multi-Ethnic Study of Atherosclerosis (MESA)), with left ventricular (LV) structure assessed by cardiac magnetic resonance (CMR)
- Participants
- 763 participants
- Outcome
- Plasma proteins cross-sectionally associated with LV size and geometry (LV mass index, LV end-diastolic volume index, LV mass-to-volume ratio)
- Follow-up
- Exam 1 (2000-2002), reproduced at exam 5 (2010-2011)
Methodological detailspopulation-based cohort (MESA), aptamer-based proteomics (1305 proteins), replication at exam 5, Multivariable linear regression with robust variance
- Population-based cohort (MESA)
- Aptamer-based proteomics (1305 proteins)
- Replication at exam 5
- Multivariable linear regression with robust variance
Main finding
As reported in the abstract
Proteins associated with LV structure at both time points, same direction (FDR < 0.05), adjusted for renal function and CVD risk factors
LV mass index: Leptin (LEP), renin (REN), cathepsin-D (CTSD)
3
LV end-diastolic volume index: LEP, NT-proBNP, EHMT2, CHRDL1, TNFAIP6, NTRK3, C5, NOTCH3, EFNB2, osteomodulin (OMD), CNTN4, gelsolin (GSN), CXCL12, PPP3R1, IGF1R, IBSP, IL-11, FSTL1, periostin (POSTN), biglycan (BGN)
20
LV mass-to-volume ratio: RGMB, TGFBR3, EFNA2, CADM3
4
Observational data: associations, not effects.
Further findings
Functional annotation
- Implicated PI3K-Akt pathway regulation, bone morphogenic protein signalling and cGMP-mediated signalling
Original publication
Proteomics of Left Ventricular Structure in the Multi-Ethnic Study of Atherosclerosis. ESC Heart Fail. Published 12 September 2024. doi:10.
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