Heart failure & cardiomyopathies

Prognosis of Early-Stage Heart Failure with Preserved Ejection Fraction (HFpEF) in the Community-Dwelling Elderly: The Northern Shanghai Study

ESC Heart FailPublished Prospective cohort study

Authors' conclusion

Compared with those with HFpEF stage 0, patients with HFpEF, whether in stage B or C, exhibit significantly higher cardiovascular and all-cause mortality in the elderly.

Study context

Population
Community-dwelling individuals aged over 65 from northern Shanghai1,623 included
Participants
1,789 individuals
Exposure
HFpEF stages A, B and C vs stage 0
Outcome
MACE, all-cause death and CV death
Follow-up
Mean 7.10 ± 1.27 years
Methodological detailscommunity-based
  • Community-based

Main finding

As reported in the abstract

MACE
Cox regression
Each group vs HFpEF stage 0Hazard ratio (95% CI)P value
HFpEF stage A
2.97(1.13–7.82)
P < 0.05
HFpEF stage B
2.69(1.09–6.64)
P < 0.05
HFpEF stage C
4.86(1.88–12.59)
P < 0.01
Stages A, B and C had more MACE than stage 0
P < 0.01
Stage C had significantly higher CV death ratio
P < 0.001
Stage C had significantly higher all-cause death ratio
P < 0.01

Observational data: associations, not effects.

Original publication

Prognosis of Early-Stage HFpEF in the Community-Dwelling Elderly: The Northern Shanghai Study. ESC Heart Fail. Published 12 September 2024. doi:10.1002/ehf2.15060

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