Psychiatric morbidity and work participation in patients with congenital ventricular septal defects: a case-controlled study
Main finding · Any psychiatric disorderResult — go to the resultHazard ratio 1.24 95% CI 1.17–1.32Authors' conclusion
Patients with isolated VSD suffer from a higher burden of psychiatric disorders and display lower work participation compared with matched controls from the general Danish population.
Study context
- Population
- Danish patients with isolated congenital ventricular septal defects (VSD) born before 2018
- Participants
- 8,006 vs 79,568
- Exposure
- Isolated congenital VSD vs matched general-population controls
- VSDn = 8,006
- Controlsn = 79,568reference
- Outcome
- Any psychiatric disorder
- Follow-up
- Median 23 years
Methodological detailsnationwide registries, matched by age and sex
- Nationwide registries
- Matched by age and sex
Main finding
As reported in the abstract
Hazard ratio
1.24
95% CI 1.17–1.32
VSDvs Controls
HR 1.24 (95% CI 1.17–1.32)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Intellectual disabilities | 3.66 (2.98–4.50) | |
| Use of psychotropic agents | 1.14 (1.09–1.20) | |
| 0.20.5125Hazard ratio (log scale) |
Work participation
- Lower in VSD vs controls
- P < 0.001
- Lower in VSD with vs without psychiatric disorder
- P < 0.001
Permanent social security benefits, cumulative incidence · 40 years
- With psychiatric disorders: VSD vs controls
- 29% vs 21%
- Without psychiatric disorders: VSD vs controls
- 8% vs 4%
Original publication
Psychiatric morbidity and work participation in patients with congenital ventricular septal defects: a case-controlled study. Eur Heart J Qual Care Clin Outcomes. Published 4 January 2024. doi:10.
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