Aortic coarctation and long-term morbidity after arterial switch operation: a multicentre international cohort study
Main finding · Time to first right ventricular outflow tract (RVOT)-related interventionResult — go to the resultHazard ratio 2.62Authors' conclusion
Among adults post-ASO, CoA-not VSD-is the dominant anatomical driver of long-term morbidity. These patients require targeted surgical attention and structured, lifelong follow-up to mitigate future complications.
Study context
- Population
- Adults with dextro-transposition of the great arteries after the arterial switch operation (ASO), EPOCH-ASO multicentre registry (median age 25.5 years)adults analysed
- Participants
- 502 adults
- Exposure
- Association of coarctation (CoA) and VSD (complex anatomy) with interventions and cardiovascular complications, adjusted Cox regression and Andersen-Gill models
- Outcome
- Time to first right ventricular outflow tract (RVOT)-related intervention
Methodological detailsregistry
- Registry
Main finding
As reported in the abstract
Hazard ratio
2.62
Observational data: associations, not effects.
Secondary outcomes
| Outcome | HR |
|---|---|
| LVOT-related interventions | 10.75 |
| Cardiovascular complications | 2.16 |
VSD (complex anatomy) associations
- VSD (complex anatomy) showed weaker or no associations
Recurrence of right ventricular outflow tract (RVOT) and left ventricular outflow tract (LVOT) interventions
- CoA also predicted higher recurrence rates of both RVOT and LVOT interventions
Original publication
Aortic coarctation and long-term morbidity after arterial switch operation: a multicentre international cohort study. Heart. Published 23 July 2025. doi:10.
Summarised from the published abstract; every number is checked against it