Psychological Distress and the Risk of Adverse Cardiovascular Outcomes in Patients With Coronary Heart Disease
Authors' conclusion
Among patients with CHD, a composite measure of psychological distress was significantly associated with an increased risk of adverse events and significantly improved risk prediction.
Study context
- Population
- Patients with stable coronary heart disease (CHD); distress score from depression, anxiety, anger, perceived stress and PTSD measured at baseline
- Participants
- 891 patients · 2 cohorts
- Comparison
- Highest and middle vs lowest tertile of psychological distress score
- Outcome
- CV death or first or recurrent nonfatal MI or hospitalization for HF
- Follow-up
- 5.9 years
Pooled result
As reported in the abstract
CV death, nonfatal MI or HF hospitalization (first and recurrent events)
Each group vs lowest tertileHazard ratio (95% CI)
Highest tertile
2.27(1.69–3.06)
Middle tertile
1.52(1.10–2.08)
Further pooled results
Risk prediction (distress score added to clinical risk model)
- C-statistic, net reclassification index and integrative discrimination index all significantly improved
Original publication
Psychological Distress and the Risk of Adverse Cardiovascular Outcomes in Patients With Coronary Heart Disease. JACC Adv. Published 22 December 2023. doi:10.
Summarised from the published abstract; every number is checked against it