Congenital heart diseaseCohort study
Pulmonary Artery Hypoplasia in Neonates With Tetralogy of Fallot
- Retrospective cohort study
- multicentre registry (Congenital Cardiac Research Collaborative)
Authors' conclusion
Despite perception, the presence of hPA in neonates with sTOF conferred no increase in overall hazard of mortality or reintervention after definitive repair. PA growth was superior in the hPA cohort.
Study context
- Population
- Neonates with symptomatic tetralogy of Fallot, 2005–2017
- Participants
- 542 neonates
- Exposure
- Hypoplastic pulmonary artery (PAs) vs normal PAs
- Hypoplastic pulmonary arteries (hPA)n = 188
- Normal PAn = 354reference
- Outcome
- Mortality
- Follow-up
- Median 4.1 years
Main finding
As reported in the abstract
Survival
Survival similar between groups (unadjusted)
P = 0.16
Survival similar between groups (adjusted)
P = 0.25
Observational data: associations, not effects.
Secondary outcomes
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Reintervention · overall | 1.28 (1.01–1.63) | P = 0.044 | |
| Reintervention · after definitive repair | 1.21 (0.93–1.58) | P = 0.16 | |
| 0.512Hazard ratio (log scale) |
Staged repair (vs primary TOF repair)
- Staged repair (vs primary TOF repair): P = 0.07
PA growth · 1 year
- Greater PA growth in hPA cohort, particularly right PA
- P < 0.001
Original publication
Pulmonary Artery Hypoplasia in Neonates With Tetralogy of Fallot. J Am Coll Cardiol. Published 15 August 2023. doi:10.1016/j.jacc.2023.05.051
Summarised from the published abstract; every number is checked against it