Arrhythmias & electrophysiology
Pulmonary Vein Myocardial Sleeve Length and its Association With Sex and 4q25/PITX2 Genotype
Main finding · PV sleeve lengthResult — go to the resultDifference 2.94 mm 95% CI 0.99–4.90Authors' conclusion
Common genetic variation at 4q25 was not associated with PV sleeve length and PV sleeve length was not associated with ablation outcomes. Men did have longer PV sleeves than women
Study context
- Population
- Patients undergoing de novo atrial fibrillation (AF) ablation, 2014–2019
- Participants
- 197 patients
- Exposure
- Clinical and genetic risk factors vs pulmonary vein (PV) sleeve length
- Menn = 133
- Outcome
- PV myocardial sleeve length (electroanatomic voltage mapping) by clinical and genetic (4q25, rs2200733) risk factors, multivariable linear regression
Main finding
PV sleeve length
Difference
2.94 mm
95% CI 0.99–4.90
P < 0.001
Menvs Women
difference 2.94 mm (95% CI 0.99–4.90); P < 0.001
As reported in the abstract
- One 4q25 risk allele
- Sixty participants (30.5%)
- Two 4q25 risk alleles
- 6 (3.1%)
Observational data: associations, not effects.
Further findings
Atrial arrhythmia recurrence (>30 s) after ablation · 3 to 12 months
- Recurrence
- Forty-six participants (23.4%)
- No association between recurrence and PV sleeve length
Original publication
Pulmonary Vein Myocardial Sleeve Length and its Association With Sex and 4q25/PITX2 Genotype. JACC Clin Electrophysiol. Published 22 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →